MyPGMEE presents High
Yield Topics for fast revision that will help you prepare for Medical PG
entrance exams like AIPGMEE, NEET PG, DNB CET, AIIMS PG, JIPMER, and UPSC. These
short topics will act as revision nuggets
and aid recall during the exam, for more such tips please visit www.mypgmee.com
/ download mypgmee app. Join our facebook group: crack aipgmee with Dr. Mudit
Khanna to interact with Authors and fellow Students.
MyPGMEE Authors: Dr. Mudit Khanna, Dr. Sushant Bhanja, Dr. Punit Bhojani and Dr. Ashwin Singh Parihar.
HYT – PAGET’S DISEASE
1. Increased bone turnover (Therefore elevated serum ALP and urine Hydroxyproline levels) with abnormal internal architecture leading to thick, but brittle bones.
2. High incidence in Europe, America, relatively rare in Asian countries, M=F, common in >50 yrs age
3. Familial involvement +
4. Link with viral infection suggested as probable etiology
5. Both Osteoblastic and Osteoclastic activities are elevated
6. Most common sites – Pelvis, Tibia
7. Most patients – ASYMPTOMATIC, incidental diagnosis on X-ray for other cause or elevated S. ALP levels
8. Clinical Features – Dull aching pain, deformities of extremity bones that later complicate as fractures, esp. anterior bowing of tibia, skin over the deformed bone appears warm (Osteitis deformans is therefore a synonym used for Paget’s disease), enlarged skull, Platybasia.
9. Cranial nerve compression – 5th, 7th, 8th CN, Spinal nerve root compression
10. Increased incidence of otosclerosis, Steal syndromes
11. X-ray – Osteoporosis circumscripta, flame shaped osteolytic lesion in diaphyseal region
12. Biochemical – S.Calcium and S.Phosphate – Normal. RAISED S.ALP, U.hydroxyproline
13. Risk of malignant transformation is around 1% with very poor prognosis.
14. Specific treatment to be considered if – Persistent bone pain, repeated fractures, high output cardiac failure, hypercalcemia due to immobilization, neurological complications
15. Treatment options – Calcitonin, Bisphosphonates
MyPGMEE Authors: Dr. Mudit Khanna, Dr. Sushant Bhanja, Dr. Punit Bhojani and Dr. Ashwin Singh Parihar.
HYT – PAGET’S DISEASE
1. Increased bone turnover (Therefore elevated serum ALP and urine Hydroxyproline levels) with abnormal internal architecture leading to thick, but brittle bones.
2. High incidence in Europe, America, relatively rare in Asian countries, M=F, common in >50 yrs age
3. Familial involvement +
4. Link with viral infection suggested as probable etiology
5. Both Osteoblastic and Osteoclastic activities are elevated
6. Most common sites – Pelvis, Tibia
7. Most patients – ASYMPTOMATIC, incidental diagnosis on X-ray for other cause or elevated S. ALP levels
8. Clinical Features – Dull aching pain, deformities of extremity bones that later complicate as fractures, esp. anterior bowing of tibia, skin over the deformed bone appears warm (Osteitis deformans is therefore a synonym used for Paget’s disease), enlarged skull, Platybasia.
9. Cranial nerve compression – 5th, 7th, 8th CN, Spinal nerve root compression
10. Increased incidence of otosclerosis, Steal syndromes
11. X-ray – Osteoporosis circumscripta, flame shaped osteolytic lesion in diaphyseal region
12. Biochemical – S.Calcium and S.Phosphate – Normal. RAISED S.ALP, U.hydroxyproline
13. Risk of malignant transformation is around 1% with very poor prognosis.
14. Specific treatment to be considered if – Persistent bone pain, repeated fractures, high output cardiac failure, hypercalcemia due to immobilization, neurological complications
15. Treatment options – Calcitonin, Bisphosphonates
Brought to you by
www.mypgmee.com – the
most effective online pg entrance preparation tool.
Make the best use
of your time with anytime, anywhere content availability with MyPGMEE. Improve
your scores, revise and master the topics of your choice; MyPGMEE provides you
with concise and well referenced explanations that help you gear up for the exam
effectively. MyPGMEE has been able to achieve a high strike rate in all major
medical pg entrance exams like: AIPGMEE, NEET PG, DNB CET, AIIMS PG, JIPMER, and UPSC. MyPGMEE makes the
preparation for Medical PG entrance exams interactive as you can challenge
fellow aspirants on selected topics and see your progress on a Leaderboard.
Also, you can analyze your performance and track your progress subject wise.
